造影剂碘普罗胺所致不良反应的主要影响因素及护理对策探讨 |
| 高文博 |
| 首都医科大学附属北京安贞医院，北京，100000 |
| 摘要：目的 探讨造影剂碘普罗胺所致不良反应的主要影响因素，并提出针对性护理对策，为临床安全用药提供参考。方法 回顾性分析 2024 年 4 月至 2025 年 4 月期间使用造影剂进行影像检查的80 例患者临床资料，采用高压注射器给药，收集患者基本信息、用药情况及不良反应发生数据。结果80 例患者中 12 例发生不良反应，总发生率为 15.00%；其中皮肤及附件损害占比最高（58.33%）。单因素分析显示，年龄≥60 岁（χ2=4.862，P=0.027）、有过敏史（χ2=6.329，P=0.012）、碘普罗胺剂量≥100mL（χ2=5.136，P=0.023）、肾功能不全（χ2=7.015，P=0.008）与不良反应发生相关；多因素 Logistic回归分析显示，有过敏史（OR=4.215，95% CI：1.326~13.382，P=0.015）、肾功能不全（OR=3.892，95%CI：1.206~12.563，P=0.023）、碘普罗胺剂量≥100mL（OR=3.157，95% CI：1.012~9.845，P=0.047）是独立危险因素。结论 过敏史、肾功能不全及高剂量碘普罗胺是不良反应发生的关键因素，临床需通过精准评估、剂量控制及针对性护理降低风险。 |
| 关健词：造影剂；碘普罗胺；不良反应；影响因素 |
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| Discussion on the main influencing factors and nursing strategies of adverse reactions caused by contrast agent iopromide |
| Wenbo Gao |
| Beijing Anzhen Hospital, Capital Medical University , Beijing , 100000,China |
| Abstract：Obective Explore the main influencing factors of adverse reactions caused by contrast agent iopromide, and propose targeted nursing strategies to provide reference for safe clinical medication. Methods Retrospective analysis of clinical data of 80 patients who underwent imaging examinations using contrast agents from February 2025 to December 2025. High pressure injection was used to collect basic patient information, medication use, and adverse reaction data. Results Out of 80 patients, 12 experienced adverse reactions, with a total incidence rate of 15.00%; Among them, skin and accessory damage accounted for the highest proportion (58.33%).Univariate analysis showed that age ≥ 60 years (χ 2=4.862, P=0.027), history of allergies (χ 2=6.329, P=0.012), iodinated propamide dose ≥ 100mL (χ 2=5.136, P=0.023), and renal dysfunction (χ 2=7.015, P=0.008) were associated with the occurrence of adverse reactions; Multivariate logistic regression analysis showed that a history of allergies (OR=4.215, 95% CI: 1.326~13.382, P=0.015), renal dysfunction (OR=3.892, 95% CI: 1.206~12.563, P=0.023), and a dose of iodoprolol ≥ 100mL (OR=3.157, 95% CI: 1.012~9.845, P=0.047) were independent risk factors. Conclusion Allergic history, renal dysfunction, and high-dose iodinated propamide are key factors in the occurrence of adverse reactions. Clinical practice requires precise assessment, dose control, and targeted nursing to reduce risks. |
| Keywords：Contrast agent; Iodoprolol; Adverse reactions; influencing factors |
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